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This the main problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both once they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight naturally can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err along the side of caution and let the FDA do its job and demand some investigation be done so the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on the medications. Researchers discovered that participants using this drug for a year, lost weight within a month and have kept the load off through the entire 56 weeks in the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more efficient and safer. Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular could be the fact that since right now there are not any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure and heartbeat, and really should not be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. New UCLA study on smokers with mental, drug, and alcohol problems