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Using two separate drugs to lose weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err along the side of caution and allow the FDA do its job and demand some investigation be done so the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on his or her medications. Researchers discovered that participants investing in this drug for a year, lost excess weight within four weeks and have kept the extra weight off during the entire 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more potent and safer. Combo-pilling could be the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that at the time of right now there aren't long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise hypertension and heart rate, and must not be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must not be used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed within the liver right after uptake from your intestines and has no therapeutic effect. Buprenorphine may be the active substance; it is absorbed underneath the tongue (and during the entire mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who may have had gastric bypass, the location where the first area of the intestine is bypassed along with the stomach contents empty into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy in which the drug is taken up through the duodenum and transferred right to the liver by the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken on by areas of the intestine which are not served by the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.