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Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular could be the fact that since right now there are no long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug could also raise blood pressure levels and heartrate, and really should not be used in people with a history of cardiac arrest or stroke in the previous six months. 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